教授

【研究方向】生物信息学/信息挖掘/基因组学/表观基因组学；长期致力于小麦/节节麦/拟南芥/油菜等植物的基因组学/转录组学/表观基因组学等相关研究，参与组装并分析了多个作物的基因组，如小麦TGACv1，小麦IWGSC v0.4，节节麦Aet_MR1.0，小麦chr3DL等；同时，致力于生物学与计算科学交叉领域的定向信息挖掘，生物信息学技术平台的搭建/编程/应用，利用自定义编程开发生物信息学新流程/新工具（https://github.com/lufuhao）。目前，主要集中于以下几个方向：1）作物基因组学；2）多倍体化进程中基因的表达与适应；3）表观基因组学对多倍体化的贡献与影响。

【办公地点】作物国重502

【联系邮箱】lufuhao@henu.edu.cn

【教育及工作经历】2012年毕业于韩国公州国立大学（Kongju National University），获理学博士学位；2012-2019年，英国约翰英纳斯中心（John Innes Centre）博士后；2019年至今，河南大学特聘教授

【代表性论文】

7.. Fan Zhang#, Yawei Zhang, Xiaoke Zhu, Xiaopan Chen *,Fuhao Lu*, and Xinhong Zhang *. DeepSG2PPI: a protein-protein interaction prediction method based on deep learning. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 20(5): 2907-2919. doi:10.1109/TCBB.2023.3268661.

6. Charlotte N. Miller#, Jack Dumenil,Fu Hao Lu, Caroline Smith, Neil McKenzie, Volodymyr Chapman, Joshua Ball, Mathew Box, Michael Bevan *. Variation in the expression of a transmembrane protein influences cell growth in Arabidopsis thaliana petals by altering auxin responses. BMC Plant Biology 2020,20(1):482. doi: 10.1186/s12870-020-02698-5

5.Fu-Hao Lu#, Neil McKenzie, Laura-Jayne Gardiner, Ming-Cheng Luo, Anthony Hall, Michael W. Bevan *. Reduced chromatin accessibility underlies gene expression differences in homologous chromosome arms of diploidAegilops tauschiiand hexaploid wheat.GigaScience, 2020, 9(6):giaa070. doi: 10.1093/gigascience/giaa070

4.Fu-Hao Lu#, Neil McKenzie#, George Kettleborough, Darren Heavens, Matthew D. Clark, Michael W. Bevan*. Independent assessment and improvement of wheat genome sequence assemblies using Fosill jumping libraries.GigaScience,2018, 7(5): giy053. doi: 10.1093/gigascience/giy053

3. Ming-Cheng Luo#, Yong Q Gu#, Daniela Puiu#, Hao Wang#, Sven O Twardziok#, Karin R Deal, Naxin Huo, Tingting Zhu, Le Wang, Yi Wang, Patrick E McGuire, Shuyang Liu, Hai Long, Ramesh K Ramasamy, Juan C Rodriguez, Sonny L Van, Luxia Yuan, Zhenzhong Wang, Zhiqiang Xia, Lichan Xiao, Olin D Anderson, Shuhong Ouyang, Yong Liang, Aleksey V Zimin, Geo Pertea, Peng Qi, Jeffrey L Bennetzen, Xiongtao Dai, Matthew W Dawson, Hans-Georg Muller, Karl Kugler, Lorena Rivarola-Duarte, Manuel Spannagl, Klaus F X Mayer,Fu-Hao Lu, Michael W Bevan, Philippe Leroy, Pingchuan Li, Frank M You, Qixin Sun, Zhiyong Liu, Eric Lyons, Thomas Wicker, Steven L Salzberg*, Katrien M Devos*, Jan Dvorak*. Genome sequence of the progenitor of the wheat D genomeAegilops tauschii.Nature,2017, 551(7681):498-502. doi: 10.1038/nature24486

2. Bernardo J. Clavijo#, Luca Venturini#, Christian Schudoma, Gonzalo Garcia Accinelli, Gemy Kaithakottil, Jonathan Wright, Philippa Borrill, George Kettleborough, Darren Heavens, Helen Chapman, James Lipscombe, Tom Barker,Fu-Hao Lu, Neil McKenzie, Dina Raats, Ricardo H. Ramirez-Gonzalez, Aurore Coince, Ned Peel, Lawrence Percival-Alwyn, Owen Duncan, Josua Trösch, Guotai Yu, Dan M. Bolser, Guy Namaati, Arnaud Kerhornou, Manuel Spannagl, Heidrun Gundlach, Georg Haberer, Robert P. Davey, Christine Fosker, Federica Di Palma, Andrew L. Phillips, A. Harvey Millar, Paul J. Kersey, Cristobal Uauy, Ksenia V. Krasileva, David Swarbreck*, Michael W. Bevan*, Matthew D. Clark*. An improved assembly and annotation of the allohexaploid wheat genome identifies complete families of agronomic genes and provides genomic evidence for chromosomal translocations.Genome Research,2017, 27(5):885-896. doi: 10.1101/gr.217117.116

1. Hui Dong#, Jack Dumenil#,Fu-Hao Lu#, Li Na#, Hannes Vanhaeren, Christin Naumann, Maria Klecker, Rachel Prior, Caroline Smith, Neil McKenzie, Gerhard Saalbach, Liangliang Chen, Tian Xia, Nathalie Gonzalez, Mathilde Seguela, Dirk Inzé, Nico Dissmeyer, Yunhai Li*, Michael W. Bevan*. Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation inArabidopsis.Genes & Development, 2017, 31(2):197-208. doi:10.1101/gad.292235.116.

【项目/著作/专利】

【教学及人才培养】本科生课程《生物信息学》

【主要荣誉】英国皇家生物学学会会士；河南省肿瘤精准诊疗联盟创始会员