师资队伍

郑蒙

   郑蒙,男,1985年3月出生,河南大学校特聘教授。2012年6月苏州大学获博士学位 (导师:钟志远教授),博士期间赴韩国科学技术学院进行了为期3个月的联合培养(合作导师:Tae Gwan Park教授)。2012年9月至2015年11月分别在东京大学医学部和工学部工作,担任特任研究员(合作导师:Kazunori Kataoka教授)。在国际主流期刊ACS nano, Biomaterials,Journal of controlled release, Biomacromolecules,Molecular pharmaceutics等上发表论文17篇,论文总被引用超500次,H因子11。获得中国及日本专利各1项。主持日本学术振兴会(JSPS)外籍特任研究员基金1项,参与了日本大型科研计划FIRST项目及国家自然科学基金2项。主要研究领域包括先进药物输送系统用于癌症及脑相关疾病的诊断与治疗。

已发表论文:
1. Meng Zheng, Hyun Jin Kim, Hiroyasu Takemoto, Kanjiro Miyata, Kazunori Kataoka. Precisely regulated nanoarchitecture comprised of gold nanotemplate and unimer polyion complex for systemic delivery of siRNA. Journal of Controlled Release. 2015, 213: e75-e76.
2. Meng Zheng, Zhihong Zhong, Lei Zhou, Fenghua Meng, Rui Peng, and Zhiyuan Zhong. Poly(ethylene oxide) grafted with short polyethylenimine gives DNA polyplexes with superior colloidal stability, low cytotoxicity and potent in vitro gene transfection under serum conditions. Biomacromolecules, 2012, 13(3): 881-888.
3. Meng Zheng, Chunmei Yang, Fenghua Meng, Rui Peng, and Zhiyuan Zhong. pH-sensitive degradable hydrophobe modified 1.8 kDa branched polyethylenimine as “artificial viruses” for safe and efficient intracellular gene transfection. Macromolecular Research, 2012, 20(3): 327-334.
4. Meng Zheng, Yinan Zhong, Fenghua Meng, Rui Peng, and Zhiyuan Zhong. Lipoic acid modified low molecular weight polyethylenimine mediates nontoxic and highly potent in vitro gene transfection. Molecular pharmaceutics, 2011, 8(6): 2434-2443.
5. Meng Zheng, Lei Zhou, Ru Cheng, Fenghua Meng, Rui Peng, and Zhiyuan Zhong. Poly(ethyleneoxide) grafted with low molecular weight polyethylenimines for non-viral gene transfer. Journal of Controlled Release, 2011, 152: e186-e187.
6. Yuhe Wang, Meng Zheng (共同一作), Fenghua Meng, Jing Zhang, Rui Peng, and Zhiyuan Zhong. Branched polyethylenimine derivatives with reductively cleavable periphery for safe and efficient in vitro gene transfer. Biomacromolecules, 2011, 12(4): 1032-1040.
7. Zhaozhong Liu, Meng Zheng (共同一作), Fenghua Meng, Zhiyuan Zhong. Non-viral gene transfection in vitro using endosomal pH-sensitive reversibly hydrophobilized Polyethylenimine. Biomaterials, 2011, 32(34): 9109-9119.
8. Hyun Jin Kim, Hiroyasu Takemoto, Yu Yi, Meng Zheng, Yoshinori Maeda, Hiroyuki Chaya, Kotaro Hayashi, Peng Mi, Frederico Pittella, R James Christie, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS nano, 2014, 8(9): 8979-8991.
9. Hyun Jin Kim, Kanjiro Miyata, Takahiro Nomoto, Meng Zheng, Ahram Kim, Xueying Liu, Horacio Cabral, R James Christie, Nobuhiro Nishiyama, Kazunori Kataoka. siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials, 2014, 35(15): 4548-4556.
10.   Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer. Drug Delivery and Translational Research, 2014, 4(1): 50-60.
11. Wen Hu, Liang Cheng, Lifang Cheng, Meng Zheng, Qifu Lei, Ziyang Hu, Ming Xu, Lipeng Qiu, Dawei Chen. Redox and pH-responsive poly(amidoamine) dendrimer–poly(ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release.Colloids and Surfaces B: Biointerfaces, 2014, 123: 254-263.
12. Weiwei Guo, Meng Zheng, Yinan Zhong, Fenghua Meng, Chao Deng, Zhiyuan Zhong. Poly(ethylene oxide)-graft-methotrexate macromolecular drugs conjugating via aminopteridine ring exhibit potent anticancer activity. Chinese Journal of Chemistry, 2014, 32(1): 57-65.
13. Wei Chen, Meng Zheng, Fenghua Meng, Ru Cheng, Chao Deng, Jan Feijen, and Zhiyuan Zhong. In situ forming reduction-sensitive degradable nanogels for facile loading and triggered intracellular release of proteins. Biomacromolecules, 2013, 14(4): 1214-1222.
14. Caihong Zhu, Meng Zheng, Fenghua Meng, Frauke Koenig, Nadia Ruthardt, Xiulin Zhu, Zhiyuan Zhong. Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced non-viral gene transfection.Biomacromolecules, 2012, 13(3): 769-778.
15. Yinfeng Du, Wei Chen, Meng Zheng, Fenghua Meng, and Zhiyuan Zhong. pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride. Biomaterials, 2012, 33(29): 7291-7299.
16. Rongran Wei, Liang Cheng, Meng Zheng, Fenghua Meng, and Zhiyuan Zhong. Reduction-responsive disassemblable core-crosslinked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anti-cancer drug release. Biomacromolecules, 2012, 13(8): 2429-2438.
17. Shaoke Li, Fenghua Meng, Zhongjuan Wang, Yinan Zhong, Meng Zheng, Haiyan Liu, Zhiyuan Zhong. Biodegradable polymersomes with an ionizable membrane: Facile preparation, superior protein loading, and endosomal pH-responsive protein release.European Journal of Pharmaceutics and Biopharmaceutics, 2012, 82(1): 103-111.