教师名录

【研究方向】癌症生物学和转化- 多年来一直致力于类固醇激素和维生素 D 受体与肿瘤的形成和治疗的研究，由其主导的团队对前列腺、乳腺、卵巢等生殖系统肿瘤的内分泌调控进行了系统研究，其研究也触及其他实体瘤的信号传导和增殖、细胞调亡， 蛋白的磷酸化， 泛苏化，以及PTEN-FoxO，sirtuins ，mTOR等和衰老与癌症有关的信息通路，micro-RNA调控，DNA甲基化和化疗抗性机理等。近年来开展的尚未发表的研究工作重点放在了肿瘤微环境，自噬和溶酶体氨基酸转运以及蛋白能源的代谢和利用，肿瘤免疫和免疫治疗，纳米材料和靶向输送在肿瘤治疗上的应用等方向上。

【办公地点】生命科学院C317房间

【联系邮箱】10140189@vip.henu.edu.cn；wbaiful@gmail.com

【教育及工作经历】1983年毕业于兰州大学生物学系并获动物学专业学士学位, 1984考取中国科学院北京动物所硕士研究生，同年被推荐参加得中美生物化学和分子生物学合作项目(CUSBEA)考试并顺利通过后赴美留学， 于1992年毕业于University of Texas Graduate School of Biomedical Sciencesat Houston and M. D. Anderson Cancer Center并获得生化和分子生物学博士学位，博士生项目致力于癌基因和磷酸激酶的研究获得Welch Foundation Predoctoral Fellowship资助,1992年到1997年在贝勒医学院细胞生物学系做博士后，主要研究类固醇激素受体,磷酸化和信号传导以及基因转录控制、博士后曾获得NIH Endocrinology Ｔraining Ｇrant and NIH Individual Postdoctoral Fellowship； 从1997年起任University of South Florida College of Medicine病理系和H Lee Moffitt Cancer Center助理教授(tenure-track)， 2003升任副教授并获终生教职衔（Tenure），2007年升任正教授。多次担任美国国家健康总署(NIH)科学研究评审专家团成员，美国国防部国会定向医学研究（Congress Directed Medical Research Program, CDMRP）前列腺癌， 乳腺癌， 卵巢癌研究项目方面的研究评审团成员，以及美国国内外多家癌症研究基金发放机构研究项目评审。现任Scientific Reports编委和二十余家美国主流杂志的审稿人。以主持人身份从美国国家健康总署（NIH）和国家肿瘤研究所（NCI），美国国防部前列腺癌，乳腺癌，卵巢癌研究项目获得科研项目15项，科研基金总额约1300余万美元。在美国主流学会核心期刊杂志发表论文60余篇，摘要发表40余篇。研究成果曾两次登上主流杂志封面，包括自然子刊《自然细胞生物》。曾受邀在美国国内外30多家大学, 癌症中心和学术会议上做学术报告.

【代表性论文】(*通讯作者）

1. Heehyoung Lee, Feng Jiang, Qiang Wang, Santo V. Nicosia, Jianhua Yang, Bing Su and *Wenlong Bai. (2000) MEKK1 Activation of Human Estrogen Receptor and Stimulation of the Agonist Activity of 4-Hydoxytamoxifen in Endometrial and Ovarian Cancer Cells.Molecular Endocrinology14: 1882-1896

2. Pengfei Li, Santo V. Nicosia and *Wenlong Bai. (2001) Antagonism between PTEN/Mmac1/Tep-1 and Androgen Receptor in Growth and Apoptosis of Prostate Cancer Cells.Journal of Biological Chemistry276: 20444-20450

3. Heehyoung Lee and *Wenlong Bai. (2002) Inhibition of Estrogen Receptor Nuclear Export by Ligand-induced and p38-mediated Receptor Phosphorylation.Molecular and Cellular Biology22: 5835-5845

4. Pengfei Li, Heehyoung Lee, Shaodong Guo, Terry G. Unterman, Guido Jenster and *Wenlong Bai. (2003) AKT-independent Protection of Prostate Cancer Cell Apoptosis Mediated through Androgen-independent Complex Formation between Androgen Receptor and FKHR.Molecular and Cellular Biology23: 104-118

5. Feng Jiang, Pengfei Li, Albert J Fornace Jr, Santo V Nicosia, *Wenlong Bai(2003) G2/M Arrest by 1,25 dihydroxyvitamin D3 in Ovarian Cancer Cells Mediated through the Induction of GADD45 via an Exonic Enhancer.Journal of Biological Chemistry278:48030-40

6. Pengfei Li, Chunrong Li, Xiuhua Zhao, Xiaohong Zhang, Santo V. Nicosia and *Wenlong Bai.(2004) p27^Kip1Stabilization and G1 Arrest by 1,25-Dihydroxyvitamin D₃in Ovarian Cancer Cells Mediated through Down Regulation of Cyclin E/CDK2 Kinase and SCF/Skp2 Ubiquitin LigaseJournal of Biological Chemistry279(24):25260-7

7. Feng Jiang, Junying Bao, Pengfei Li, Santo V. Nicosia and *Wenlong Bai(2004) Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D₃through the down regulation of telomerase.Journal of Biological Chemistry279(51):53213-21

8. Xiaohui Zhang, Feng Jiang, Pengfei Li, Chunrong Li, Qiuping Ma, Santo V. Nicosia and *Wenlong Bai. (2005) Suppression of ovarian caner growth by synthetic vitamin D analog EB1089 in nude mice.Clinical Cancer Research11: 323-328

9. Yonghua Yang, Lucy Hou, Edward Haller, Santo V. Nicosia and *Wenlong Bai. (2005) Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.EMBO Journal24:1021-32

10. Xiaohui Zhang, Pengfei Li, Junying Bao, Santo V. Nicosia,Honggang Wang, Steven A. Enkemann and *Wenlong Bai. (2005) Suppression of Death Receptor-mediated Apoptosis by1,25-dihydroxyvitamin D₃Revealed by Microarray Analysis.Journal of Biological Chemistry.280: 35458-35468

11. Junying Bao, Chuanhai Cao, Xiaohui Zhang, Feng Jiang, Santo V. Nicosia and *Wenlong Bai. (2007). Suppression of APP signaling into nucleus by estrogens mediated through the complex formation between the estrogen receptor and Fe65.Molecular and Cellular Biology, 27:1321-1333

12. Qiuping Ma, Wei Fu, Pengfei Li, Santo V. Nicosia, Guido Jenster, Xiaohong Zhang andWenlong Bai^*(2009).Repression of AR N/C Interaction and AIB1 Recruitment by FoxO1 and Its Involvement in the Suppression of AR Activity by PTEN Tumor Suppressor.Molecular Endocrinology (Cover Story of the Feb. Issue).23: 213-225.

13. Wei Fu, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, and *Wenlong Bai, (2009). MDM2 acts downstream of p53 as E3 ligase to promote FOXO ubiquitination and degradation.Journal of Biological Chemistry.J Biol Chem.2009 May 22;284(21):13987-4000. doi: 10.1074/jbc.M901758200. Epub 2009 Mar 25.

14. Yonghua Yang, Anfernee K-W Tse, Pengfei Li, Qiuping Ma, Santo V. Nicosia, Edward Seto, Xiaohong Zhang and *Wenlong Bai,(2011) Suppression of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation.Oncogene.12;30(19):2207-18. Epub 2011 Jan 17

15. Zheng Shen, Pengfei Li, Jie Wu, Xiaohong Zhang, Santo V. Nicosia and *Wenlong Bai. (2011) The coupling of EGFR down regulation to cell cycle arrest at G1-S checkpoint induced by 1alpha,25-dihydroxyvitamin D3 in ovarian cancer cells.Molecular Cellular Endocrinology.16;338(1-2):58-67. Epub 2011 Mar 30.

16. Kasiappan Ravi, Zheng Shen, Anfernee K-W Tse, Umesh Jinwal, Jinfu Tang, Panida Lungchukiet, Yuefeng Sun, Patricia Kruk, Santo V. Nicosia, Xiaohong (Mary) Zhang, *Wenlong Bai. 1,25-dihydroxyvitamin D3 suppresses telomerase expression and human cancer cell survival through miR-498.J. Biol. Chem.2012 Nov 30;287(49):41297-309. doi: 10.1074/jbc.M112.407189.

17. Yuefeng Sun, Ravi Kasiappan, Panida Lungchukiet, Waise Quarni, Xiaohong Zhangand *Wenlong Bai. A Positive Role of the FE65 Neuronal Adaptor Protein in Estrogen Stimulation of Breast Cancer Cell Growth.J Biol Chem. 2014 May, 2;289(18):12217-31. doi: 10.1074/jbc.M113.526194. Epub 2014 Mar 11.

18. Mu Zhang, Shengyan Xiang, Heui-Yun Joo, Amanda Jones, Ryan Pavlovicz³, Huiqin Dong, Patrick Matthias⁴, Santo V. Nicosia, Jiandong Chen, Chenglong Li,Wenlong Bai, Hengbin Wang and Xiaohong Zhang. HDAC6 functions as a deacetylase and a ubiquitin E3 ligase for MSH2 degradation.Molecular Cell. 2014 Jul 3;55(1):31-46. doi: 10.1016/j.molcel.2014.04.028. Epub 2014 May 29.

19. Ravi Kasiappan, Yuefeng Sun, Panida Lungchukiet, Waise Quarni, Santo V. Nicosia, Xiaohong Zhangand *Wenlong Bai. Vitamin D Suppresses Leptin Stimulation of Cancer Growth through microRNA.Cancer Research. 2014 Nov 1;74(21):6194-204. doi: 10.1158/0008-5472.CAN-14-1702.This research paper was the subject of an article preview inNature Reviews Endocrinology10,702(2014)doi:10.1038/nrendo.2014.179.

20. Yuefeng Sun, Sun J, Lungchukiet P, Quarni W, Yang S, Zhang X, *Wenlong Bai. Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation.Scientific Reports.2015 Jul 13;5:11529. doi: 10.1038/srep11529.

21. Waise Quarni¹, Panida Lungchukiet¹, Yuefeng Sun¹, Ravi Kasiappan¹, Anfernee Tse¹, Xiaohong Zhang^1,2,3, *Wenlong Bai. RIPK1 binds to vitamin D receptor and decreases vitamin D induced growth suppression.Journal of Steroid Biochemistry and Molecular Biology.2017 Feb 1. pii: S0960-0760(17)30034-1. doi: 10.1016/j.jsbmb.2017.01.024. [Epub ahead of print].

22. Wu JY, Moses N,Bai W, Zhang XM. Implications of the HDAC6-ERK1 feed-forward loop in immunotherapy.J Immunol Sci.2018;2(3):59-68. doi: 10.29245/2578-3009/2018/3.1143. Epub 2018 Jun 13

23. Zhang M, Hu C, Moses N, Haakenson J, Xiang S, Quan D, Fang B, Yang Z,Bai W, Bepler G, Li GM, Zhang XM. HDAC6 regulates DNA damage response via deacetylating MLH1.J Biol Chem.2019 Feb 15. pii: jbc.RA118.006374. doi: 10.1074/jbc.RA118.006374. [Epub ahead of print]

24. Chen Hu, Mu Zhang, Niko Moses, Cong-li Hu, Lisa Polin, Wei Chen, Hyejeong Jang, Joshua Heyza, Agnes Malysa, Joseph A. Caruso, Shengyan Xiang, Steve Patrick, Paul Stemmer, Zhenkun Lou,Wenlong Bai, Chuangui Wang, Gerold Bepler, and Xiaohong Mary Zhang. The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53.Cell Death Dis. 2020 May; 11(5): 328. Published online 2020 May 7. doi: 10.1038/s41419-020-2519-8

25. doi: 10.3390/cells9102237. Tingting Ren, Haotai Chen, Xinsheng liu, Yanxue Wang, Aixia Fan, Linlin Qi, Wenlong Bai*, Yongguang Zhang*& Yuefeng Sun* ID1 inhibits foot-and-mouth disease virus replication via targeting interferon pathways. FEBS Letter. 288, 4364-4381, First published: 25 January 2021 https://doi.org/10.1111/febs.15725.

    【项目/著作/专利】

    Book Chapter:Xiaohong Zhang, Tung I. Hsieh, Santo V. Nicosia, *Wenlong Bai. (2007). The role of Sirtuins in aging and tumorigenesis. CRC Press (Taylor & Francis Group), "CANCER EPIGENETICS", Ed: Trygve Tollefsbol. Chapter 9, P151-180.

    U.S. Provisional Patent Application:

    Title: “Use of Vitamin D3 Analogues for Prevention and Treatment of Parkinson's Disease.” USF Ref. No.: 10A047PR2. Date filed: July 6, 2011

    【教学及人才培养】以博士导师身份已经培养博士生和博士后人员二十余名，多名博士生获优秀毕业论文奖或个人研究专项基金资助（Predoctoral Fellowship）， 近半数博士后已在中美两地高等院校任教授。主讲课程：Nuclear Hormone Receptors/Steroid Hormones and Cancer/Cancer Biology/Foundation in Biomedical Sciences – Molecular Biology of the Cell/Pathology of Human Cancer/Evidence-based Clinical Reasoning/Principles of Molecular Medicine etc.

    【主要荣誉】

26. 2007–2010: Dean’s Academic Performance Awards, USF College of Medicine

27. 2005: Recognized in USF as a Million Dollar Researcher for Outstanding Research Achievements

28. 2005: Recipient of 2005 Moffitt Cancer Center Team Award (as a member of theMoffitt- FAMU Grant Team)

29. 1994–1997: Individual Research Fellowship Award, NIH, 1 F32 DK09151-01

30. 1993 – 1994: Training Grant Award in Molecular Endocrinology, NIH T32 DK 07696

31. 1988 –1992: Pre-doctoral Fellowship Award, Welch Foundation, G1118

32. 1984:CUSBEAFellow: China-United States Biochemistry and Molecular Biology Examination and Application Program (CUSBEA program)