教授

【研究方向】

肿瘤生物学，生物医学

【办公地点】

河南大学生命科学学院C316

【联系邮箱】

yongpingjian123@163.com

【教育及工作经历】

2025/07-至今 河南大学 生物医学 百人计划A岗

2022/07-2025/07 河南大学 生物医学 博士后

2019/09-2022/06 吉林大学 病理学 博士

2016/09-2019/06 吉林大学 病理学 硕士

2011/09-2016/06 大连医科大学 医学 学士

【代表性论文】

1. He KY, Zhao A, Guo JR, Wu DH, Liu H, Gao F, Liu MJ, Yang JY, Lei XY, Li JQ, Zhang L, Yan ZH, Ding Q, Huang YW, Cui RT*, Jian YP*, and Xu ZX*. HMGA1 promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity. Nature Communications. 2025; 16(1): 5098. (通讯作者)

2. Zhao Y, Liu MJ, Zhang L, Yang Q, Sun QH, Guo JR, Lei XY, He KY, Li JQ, Yang JY, Jian YP*, Xu ZX*. High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis. Nature Communications. 2024; 15(1): 9909. (通讯作者)

3. He KY, Guo JR, Lu HH, An W, Zhao Y, Zhao JY, Li JQ, Lei XY, Liu H, Yan ZH, Ai PH, Jian YP*, Wang ZC*, Xu ZX*. Honglian extract (HLE) alleviates colitis by inhibiting ferroptosis in intestinal epithelial cells. Food Science and Human Wellness. 2025; Accepted. (通讯作者)

4. Zhang L, Zhu LJ, Zhao Y, Lei XY, Wu DH, He KY, Liu MJ, Yang JY, Jiang ZH, Guo JR, Yan ZH, Xu ZX*, Jian YP*. STING inhibits the progression of esophageal squamous cell carcinoma by suppressing CPT1A-mediated fatty acid β-oxidation. Acta Pharmacologica Sinica. 2025; Online. (通讯作者)

5. Lei XY, He KY, Li QT, Zhang L, Wu DH, Yang JY, Guo JR, Liu MJ, Zhao ZL, Li JQ, Liu H, Zhao Y, Li YJ, Sun QH, Wu CG, Wang YF, Cao GS, Wang G, Jian YP*, Xu ZX*. PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib. Clinical and Translational Medicine. 2024; 14: e70111. (通讯作者)

6. Wu DH, Zhao ZL, Yin WT, Liu H, Xiang XY, Zhu LJ, Li JQ, Yan ZH, Li YJ, Jian YP*, Xu ZX*. STING exerts antiviral innate immune response by activating pentose phosphate pathway. Cell Communication and Signaling. 2024; 22: 599. (通讯作者)

7. Liu MJ, Zhao Y, Li QT, Lei XY, He KY, Guo JR, Yang JY, Yan ZH, Wu DH, Zhang L, Jian YP*, Xu ZX*. HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway. Cell Death & Disease. 2024 Jul 30; 15(7): 541. (通讯作者)

8. Guo JR, He KY, Yuan JL, An W, Yin WT, Li QT, Lu LY, Yang JY, Liu MJ, Li YJ, Zhao Y, Yang Q, Lei XY, Gao F, Zhang L, Wu DH, Li JQ, Zhao ZL, Liu H, Zhu LJ, Xiang XY, Sun QH, Jian YP*, Xu ZX*. HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis. International Journal of Biological Sciences. 2024 Apr 22; 20(7): 2640 - 2657. (通讯作者)

9. He KY, Lei XY, Wu DH, Zhang L, Li JQ, Li QT, Yin WT, Zhao ZL, Liu H, Xiang XY, Zhu LJ, Cui CY, Wang KK, Wang JH, Lv L, Sun QH, Liu GL*, Xu ZX*, Jian YP*. Akkermansia muciniphila protects the intestine from irradiation-induced injury by secretion of propionic acid. Gut Microbes. 2023 Dec; 15(2): 2293312. (通讯作者)

10. Yang JY, Lei XY, He KY, Guo JR, Liu MJ, Li JQ, Li QT, Jiang ZH, Zhang L, Wu DH, Li YJ, Sun QH, Jian YP*, Xu ZX*. HMGA1 drives chemoresistance in esophageal squamous cell carcinoma by suppressing ferroptosis. Cell Death & Disease. 2024 Feb 21; 15(2): 158. (通讯作者)

11. He KY, Lei XY, Zhang L, Wu DH, Li JQ, Lu LY, Laila UE, Cui CY, Xu ZX*, Jian YP*. Development and management of gastrointestinal symptoms in long-term COVID-19. Frontiers in Microbiology. 2023 Dec 14; 14: 1278479. (通讯作者)

12. Yang JY, Liu MJ, Lv L, Guo JR, He KY, Zhang H, Wang KK, Cui CY, Yan BZ, Du DD, Wang JH, Ding Q, Liu GL, Xu ZX*, Jian YP*. Metformin alleviates irradiation-induced intestinal injury by activation of FXR in intestinal epithelia. Frontiers in Microbiology. 2022 Oct 13; 13: 932294. (通讯作者)

13. Wang KK, He KY, Yang JY, Liu MJ, Guo JR, Liang JY, Wang JH, Xu ZX* and Jian YP*. Lactobacillus suppresses tumorigenesis of oropharyngeal cancer via enhancing anti-tumor immune response. Frontiers in Cell and Developmental Biology. 2022 Mar 1; 10: 842153. (通讯作者)

14. Liu MJ, Yang JY, Yan ZH, Hu S, Li JQ, Xu ZX*, Jian YP*. Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases. Clinical Nutrition. 2022; 41: 2333 - 2344. (通讯作者)

15. He KY, Lu LY, Jian YP*, Xu ZX*. Editorial: Induced Cell Senescence as a Therapeutic Strategy for Cancer Treatment. Frontiers in Oncology. 2022; 12: 1104877. (通讯作者)

16. Jian YP, Yang G, Zhang LH, Liang JY, Zhou HL, Wang YS, and Xu Z-X. Lactobacillus Plantarum alleviates irradiation-induced intestinal injury by activation of FXR-FGF15 signaling in intestinal epithelia. Journal of Cellular Physiology. 2022 Mar; 237(3): 1845 - 1856. (第一作者)

17. Jian YP, Zhang D, Liu MD, Wang YS and Xu Z-X. The Impact of Gut Microbiota on Radiation-Induced Enteritis. Frontiers in Cellular and Infection Microbiology. 2021 Jul 29; 11: 586392. (第一作者)

【项目】

1. 中国科协技术学会，第十届中国科协“青年人才托举工程”（2024-2026）项目，2025-01至2027-12，30万，主持，在研

2. 国家自然科学基金委员会，国家自然科学基金青年科学基金项目，82400658，2025-01至2027-12，30万，主持，在研

3. 河南省科技厅，2025年度河南省重点研发与推广专项（科技攻关）项目，252102311069，2025-01至2026-12，10万，主持，在研

4. 中国博士后科学基金会，中国博士后科学基金第18批特别资助，2025T180388，2026-01至2027-12，18万；河南省人事厅免评审配套，18万，均为主持，在研

5. 中国博士后科学基金会，中国博士后科学基金第72批面上项目，2022M721014，2023-01至2024-12，8万；河南省人事厅免评审配套，4万，均为主持，已结题

6. 河南省科技厅，2023年度河南省重点研发与推广专项（科技攻关）项目，232102311034，2023-01至2024-12，10万，主持，已结题

7. 河南省菌类食品工程技术研究中心，河南省菌类食品工程技术研究中心开放课题，HM202202，2022-07至2025-10，10万，主持，在研

8. 科技部，国家重点研发计划“政府间国际科技创新合作”重点专项，2023YFE0109800，2023-10至 2025- 09，200万，参加，在研

【教学及人才培养】

聘期内带教本科生团队获得“第九届全国大学生生命科学竞赛”国家三等奖，河南省二等奖。(均为第一指导教师)

【主要荣誉】

1. 第十届中国科协青年托举人才

2. 2025年度河南省教育厅科技成果奖优秀科技论文奖（二等奖）